NIH R01 · 2024
Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma
Summary Multiple myeloma (MM) is characterized by the growth of malignant plasma cells in the bone marrow supported by increased angiogenesis. Despite significant advances in treatments, MM remains incurable due to frequent relapses originating from MM cells refractory to therapy. Further, MM induces a devastating bone disease, increasing fracture risk and decreasing quality of life. The long-term goal of this proposal is to improve clinical outcomes in MM by defining targetable mechanisms underlying MM growth, responses to therapy, and bone destruction. The rationale stems from work from the previous funding period demonstrating that osteocytes (Ots) are an abundant and long-lived source…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.