NIH R01 · 2024
ABSTRACT Background: We recently revealed that glioblastoma (GBM) contain cell populations with distinct metabolic requirements, with fast-cycling cells (FCCs) harnessing aerobic glycolysis, and treatment-resistant slow-cycling cells (SCCs) preferentially engaging lipid metabolism. How the different tumor cells interact with immune cells and how this metabolic heterogeneity shapes the immune landscape in GBM has yet to be understood. Objectives/Hypothesis: The objectives of this study are to understand the mechanisms of communication in the tumor microenvironment, specifically to characterize the metabolic interactions between SCCs (a therapeutically resistant population that drive disease…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.