Deleon-Pennell Lab

Research focus

NIH R01 · 2024

Temporal effects of CD8 T-cells post-MI

Summary: For patients who have a heart attack (myocardial infarction; MI), 1 in 3 will not survive 5 years after the event. Therefore, there is a critical need to facilitate the long-term goal of providing potential intervention targets to prevent, slow, or reverse progression to heart failure in heart attack patients. The long-term goal of the proposal is to understand how CD8+ T-cells are impairing the wound healing response after MI leading to eventual development of heart failure. The specific objective is to understand the temporal changes in the genetic and physiological profiles of the CD8+ T-cell population and how this regulates cardiac wound healing after a heart attack. The…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.