NIH R01 · 2024
Impact of mitochondrial genetics on muscle oxidative capacity, fitness, and mobility in older adults
PROJECT SUMMARY Older adults experience a loss of mobility that leads to disability, which is a serious health care issue in an aging US population. Furthermore, the incidence of mobility disability is greater in older African Americans compared to Caucasians. The mechanisms behind these observations are not well understood. We have shown that mitochondrial function is a key property of skeletal muscle that supports walking speed, physical function, and cardiorespiratory fitness in older adults. Cross-sectional and longitudinal studies reveal lower levels of mitochondrial content and function, lower cardiorespiratory fitness and slowing walking speed with aging. We recently demonstrated…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.