NIH R01 · 2025
MicroRNAs as Diagnostic and Prognostic Biomarker of Alzheimer's Disease
ABSTRACT Preventative and therapeutic strategies for late onset Alzheimer’s Disease (AD) depend on access to reliable biomarkers for early detection, ideally minimally invasive and inexpensive with more invasive and costly ones reserved for subsequent diagnostics. Despite the progress in the development of blood biomarkers to detect AD- associated beta-amyloid or Tau pathology, the challenges remain because AD is characterized by dysregulated neural gene expression triggered by combinations of genetic and environmental risk factors. Genome-environment interactions are orchestrated by epigenetic processes that include the function of microRNAs (miRNAs, miRs) which is to regulate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.