NIH R01 · 2024
Insulin-Like Growth Factor-1 and Atherosclerosis
PROJECT SUMMARY / ABSTRACT Coronary heart disease is a primary contributor to cardiovascular disease worldwide. Despite optimal treatment many patients remain vulnerable to ischemic events. While small animal models have proven extraordinarily effective at exploring mechanisms, studies in large animal models are critically needed, as a bridge between rodent studies and human trials, and to develop new therapies. We have shown that insulin-like growth factor-1 (IGF-1) reduces atherosclerotic burden and promotes features of plaque stability in Apoe-/- mice and in Rapacz swine with familial hypercholesterolemia (FH pigs). Our novel findings indicate that IGF-1 reduces the number of senescent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.