NIH R01 · 2025
PROJECT SUMMARY Heart failure with preserved ejection fraction (HFpEF) is a public health problem affecting more than 26 million people worldwide. Currently, there are no effective strategies for managing HFpEF and projections indicate that its prevalence will double by the next decade. In the past years, we have been able to provide compelling evidence to support the pivotal role played by pre-sympathetic neurons located in the ventral aspect of the medulla (RVLM-C1) on experimental HFpEF pathophysiology, by orchestrating autonomic, cardiac, and respiratory failure during disease progression, since their selective ablation reduces sympathetic activity and arrhythmogenesis, restored normal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.