NIH R01 · 2025
The role of Neurofibromin 2 in heart failure
Project Summary The heart is a metabolically demanding organ, and derangements in metabolic processes lead to energetic deficits, generation of toxic metabolites, and redox imbalance, which drive pathogenesis to heart failure. However, current therapies for heart failure do not address this fundamental issue, and there remains an unmet clinical need for effective mechanism-based treatments. Altered transcriptional programs are thought to contribute significantly to impaired mitochondrial oxidative phosphorylation and insufficient energy production in heart failure. The estrogen-related receptors (ERRa, b, and g) are key regulators of mitochondrial respiration that are downregulated in the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.