Airola Lab

Research focus

NIH R01 · 2025

Developing new antifungals against sterolglycosidases

ABSTRACT Invasive fungal infections are a leading cause of death in immunocompromised patients. While much is known about the cellular processes required for the pathogenesis of these infections, translating understanding into tangible clinical benefit has been difficult because these fungal pathogens and their hosts have similar physiology. As a result, current antifungal agents have limited clinical efficacy, are poorly fungicidal in the host, are occasionally toxic, and are increasingly ineffective due to emerging resistance. Thus, innovative antifungal agents are needed. In previous studies, the steryl-glucosidase 1 (SGL1) gene was deleted in Cryptococcus neoformans (Cn) and its homolog…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.