NIH R01 · 2025
Structural Annotation of the Human Genome
PROJECT SUMMARY Cells must regulate their genome so that genes are expressed in the appropriate cell type, and at the correct time. Further, as cells go through the cell cycle chromosomes must be replicated, compacted and then faithfully segregated. All these processes require correct folding of the genome. Defects in folding, e.g., the looping of genes to incorrect distal enhancers, or incorrect chromosome compaction during mitosis, can lead to genes being expressed in the wrong place and at the wrong time, or to genome instability. Such defects can lead to diseases including cancer. There has been tremendous progress in identifying folding principles of chromosomes, how folding changes…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.