Dekel Lab

Massachusetts General Hospital

Boston · United States

NIH-funded
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NIH R01 · 2025

Defining postpartum PTSD and its implications for maternal wellness and child development

PROJECT SUMMARY. Maternal mental illness following childbirth is associated with substantial societal costs. Postpartum psychopathology is a leading contributor of maternal morbidity and mortality and can endanger the child’s wellbeing onward from birth. Deprivation of maternal care during the early neonatal period can induce long-term epigenetic alterations in a model animal, suggesting that postpartum mental illness can confer intergenerational risks. While efforts exist to reduce postpartum depression, childbirth-related posttraumatic stress disorder (CB-PTSD), a condition that is estimated to affect 240,000 American women each year, is underdiagnosed and undertreated. Risk factors for…

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