NIH R01 · 2024
SUMMARY Dental caries is a polymicrobial disease that affects much of the human population worldwide, where the equilibrium of a cooperative eco-organization among commensal microbes shifts towards a dysbiotic framework with an overrepresentation of pathogenic microorganisms, especially by Streptococcus mutans (SM). The progression of this disease begins with bacterial attachment and a complex cascade of events that include the production of soluble (a-1,6-linked) and insoluble (a-1,3-linked) glucans by glucosyltransferases (Gtfs) from the GH70 hydrolase family. This class of enzymes utilizes dietary sucrose to produce various isomeric glucan polymers through two important steps: (i) first…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.