NIH R01 · 2024
PROJECT SUMMARY/ABSTRACT Development of effective therapies is an urgent, unmet medical need for patients with pancreatic ductal adenocarcinoma (PDAC). The advent of immune checkpoint antagonists such as anti-PD-1 and anti-CTLA4 antibodies has revolutionized treatment of some cancers but remains unsuccessful in PDAC. We and others showed that the tumor microenvironment (TME) of PDAC is rife with myeloid-derived suppressor cells including inflammatory monocytes (IMs) and tumor-associated macrophages (TAMs) that stifle the effect of chemotherapy and anti-tumor immunity. Excessive production of CCL2 in PDAC has shown to result in tumor growth, dissemination, local immunosuppression, and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.