NIH R01 · 2024
Autophagy regulation of apoptosis and necroptosis within cell populations
An important unsolved question in cell death is to understand why different cells within a population vary in their responses. Which cells will live or die and what determines exactly how they die after exposure to a death stimulus? These questions underlie fundamental cell fate decisions and also have important practical ramifications, for example, during cancer therapy when non-heritable, heterogeneous responses to anti-cancer drugs underlie the eventual acquisition of resistance to therapy. Heterogeneity in cell responses can be driven by stable genetic differences between cells, which are easy to understand. However, such differences also occur even in genetically homogeneous cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.