NIH R01 · 2025
Metallothionein-Zinc Axis and Macrophage Memory to Fungi
Project Summary Fungal infection with Histoplasma species (Hc) is highly prevalent in the Ohio and Mississippi river valley regions of the US and is a frequent cause of fungal respiratory illness. Macrophages are the frontline effector cells that engulf Hc but only kill yeast cells upon activation. Emerging evidence indicates that macrophages and other innate cells develop a “memory” phenotype by remembering a prior microbial encounter. This process has been referred to as trained immunity. Trained macrophages manifest heightened antimicrobial defenses independent of T and B cells. Thus, training represents an alternative for improving the outcome of infection in patients with AIDS or other…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.