NIH R01 · 2025
Project Summary The discovery of brain cells-derived small extracellular vesicles (sEV), broadly known as exosomes, has led to studies examining their role as `liquid biopsies' for Alzheimer's disease and related dementias (ADRD). sEV offer a unique, repeatable, and less invasive tool to discover molecular changes in multiple cell types of the brain during Alzheimer's disease (AD) pathogenesis. Here, we propose to test the usefulness of brain cells-derived sEV to discover the molecular pathways targeted by a dietary intervention against AD and to identify individuals responsive to such intervention. Earlier studies have shown the beneficial effects of ketogenic diet (KD) against ADRD, and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.