NIH R01 · 2025
Mertk-driven regeneration of alveolar bone
ABSTRACT Partial or complete edentulism results in a loss of oral function and esthetic concerns, which diminishes a patient’s quality-of-life. Furthermore, regeneration of tissue lost after extraction is not predictable, partially due to the complexity of the repair/regenerative process. In order to be successful, the oral tissues must navigate three components of the regenerative process: 1) wound healing, 2) resolution of endogenous inflammation and 3) promoting growth and differentiation of the native bone tissue. The primary hypothesis of this proposal is that the receptor tyrosine kinase Mertk regulates early bone formation and this can be used as a therapeutic target for alveolar…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.