NIH R01 · 2025
Adenine metabolism in cardiac repair
PROJECT SUMMARY/ABSTRACT The mammalian heart does not robustly regenerate after myocardial infarction and heals via a fibrotic repair response. Scar tissue is non-contractile, increases the hemodynamic burden on the remaining cardiac muscle and over time adverse cardiac remodeling occurs leading to ventricular dilatation and development of heart failure. Understanding mechanisms of ventricular remodeling to redirect the cardiac injury response from a fibrotic to a reparative one remains one of the broad therapeutic goals in cardiovascular medicine. We have recently identified extracellular nucleotide metabolism as a novel target for cardiac remodeling after ischemic cardiac injury. We…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.