NIH R01 · 2025
Impact of Sex on Mitochondrial and Epigenetic Mechanisms in Age-Related Macular Degeneration
PROJECT SUMMARY Age-related macular degeneration (AMD), a chronic neurodegenerative condition, is the leading cause of irreversible vision loss, and more prevalent in women over 60 years. AMD cannot be prevented or cured, and is heterogeneous in its clinical presentation. The intermediate form of AMD may be a clinical biomarker indicating an increased risk of progression to either of the two advanced forms: neovascular AMD (also referred to as wet AMD), which correlates with rapid vision loss; and geographic atrophy (GA also referred to as dry AMD), in which it can take longer for vision loss to occur. Most patients are asymptomatic in the intermediate stages of AMD and do not seek clinical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.