NIH R01 · 2025
CNS-mediated fever after Adolescent Intermittent Ethanol
Project Summary/Abstract Alcohol use commonly starts in early adolescence with about 50–70% of 15 year-olds already reporting alcohol use (World Health Organization, 2018). Human and pre-clinical studies have shown that alcohol increases vulnerability to both bacterial and viral infections (Szabo, 2015), though adolescent sensitivity to the untoward effects of alcohol on immune function remain unclear. Importantly, neuroimmune function is severely altered by binge-like alcohol exposure in rodent models yet the role of CNS-mediated host defense processes has not been determined. The emergence of a global pandemic driven by widespread novel coronavirus SARS-CoV-2 and its associated disease…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.