NIH R01 · 2024
Role of VAMP1 in synaptic transmission and Alzheimer's dementia
Abstract Alzheimer’s disease (AD) is a major cause of dementia, affecting millions of elderly patients in our aging society, and thus represents a severe health care challenge. Currently available drugs may provide some temporary relief but none of them is able to halt disease progression or cure. To develop better therapies a clear understanding of the disease etiology is urgently needed. Recent data suggest the rate of synaptic activity and particularly rate of vesicle endocytosis is critically important for the processing of amyloid precursor protein (APP) into beta-amyloid (Abeta), a source of major toxic component in AD. The exact molecular mechanism connecting synaptic transmission to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.