De Vries Lab

Research focus

NIH R01 · 2024

Whole-genome sequencing analysis of coronary atherosclerosis and related traits

PROJECT SUMMARY Genome-wide association studies have identified common single nucleotide variants at over 160 genetic loci associated with coronary artery disease (CAD) and subclinical atherosclerosis (coronary artery calcification, carotid intima media thickness, and carotid plaque). These discoveries have led to important insights into the pathways that contribute to subclinical atherosclerosis and CAD, as well as insights into the genetic architecture of atherosclerosis. For example, the heritability explained by common genetic variants for CAD appears to be concentrated in regulatory regions. Nevertheless, neither the genome-wide association studies nor exome sequencing studies…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.