Dadhania Lab

Cornell University

ENGINEERING (ALL TYPES)

Ithaca · United States

NIH-funded
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NIH R01 · 2024

Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantation

PROJECT SUMMARY More than 15,000 patients receive life-saving kidney transplants in the US every year. Nevertheless, frequent post-transplant complications limit the outlook for kidney transplant recipients. Urinary tract infections (UTIs), including multi-drug antibiotic-resistant infections, occur at an alarmingly high rate after kidney transplantation. At least 20% of kidney transplant recipients experience a serious UTI in the first 3 months after transplantation. UTI has been associated with development of urosepsis, decreasing graft function, graft loss, and death. The current gold standard for diagnosis of UTI is bacterial culture, which is fundamentally limited by its ability to…

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