NIH R01 · 2025
Molecular Dissection of Proprioceptor Subclass Identity
SUMMARY The proprioceptive sense relies on multiple sensory subtypes that relay information from skin, joint, or muscle, to best estimate changes in limb dynamics. Proprioceptive muscle afferents - arguably representing the primary input into this sensory system – derive their sensory feedback information from two specialized mechano- receptive end-organs in skeletal muscle: muscle spindles (MSs), and Golgi tendon organs (GTOs). These end- organs respond to changes in muscle length or tension, respectively, and this information is routed to spinal and supraspinal motor centers through MS-groups Ia and II afferents, and GTO-group Ib afferents, which each relay qualitatively distinct features…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.