NIH R01 · 2025
The role of lysosomal impairment in trichloroethylene induced Parkinsonian neurodegeneration
Parent Project Summary Parkinson’s disease (PD) is a systemic, progressive neurodegenerative movement disorder and type of synucleinopathy characterized by the presence of misfolded α-synuclein (αSyn) protein aggregates (Lewy bodies). The majority of PD etiology is not well explained by inherited genetic risk variants, and conversely, is strongly tied to exposure to environmental contaminants, particularly industrial byproducts such as pesticides, metals, and organic solvents. Data from our lab indicates that exposure to environmental toxicants associated with PD risk impairs the autophagy-lysosomal pathway (ALP), causing aberrant proteostasis and cellular dysfunction that influences…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.