NIH R01 · 2025
Central nervous system mechanisms and treatment response in chronic ocular surface pain
ABSTRACT Chronic ocular surface pain (COSP) affects approximately 5-15% of the US population at some time in their lives at an estimated cost of over $55 billion annually. People with COSP experience painful eye burning, irritation, and aching, leading to functional impairment and decreased quality of life. Conventional treatments directed at the ocular surface – the perceived pain source – are inadequate for pain relief in over 50% of patients. We hypothesize that some individuals with COSP also suffer symptoms driven by central nervous system (CNS) dysfunction, similar to chronic overlapping pain conditions, rather than solely pathological problems in the eye. These chronic overlapping…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.