NIH R01 · 2025
Evaluating the therapeutic potential of vagal CART circuitry for treating metabolic disease
Abstract Obesity is a global crisis with severe health and economic repercussions. One of the root causes of obesity is overeating diets rich in fats and sugars. The vagus nerve is a critical conduit for gut-brain communication that senses nutrients and in turn controls feeding behavior. During the previous grant, we established novel technical advances to manipulate vagal sensory neurons in freely behaving animals and leveraged them to identify gut-brain circuits that separately control satiety and reward. The current proposal builds on that previous work to address how these circuits are changed in diet-induced obesity. We hypothesize that impaired vagal signaling develops early in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.