NIH R01 · 2024
Mechanism of the telomeric proliferation limit
Project Summary/Abstract This project focuses on the biology of telomeres, the protective elements at chromosome ends whose erosion limits the replicative lifespan of primary human cells. Telomere dysfunction has been implicated in a number of human diseases, including inherited bone marrow failure syndromes and cancer. We aim to understand how telomeres protect chromosome ends and how they are maintained. Insights into these issues resulted from our studies of shelterin, the six-subunit protein complex that binds to telomeric DNA. Shelterin is anchored on telomeres by two telomeric DNA binding proteins, TRF1 and TRF2, which promote telomere replication and protect telomeres from the DNA…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.