NIH R01 · 2024
Role of secreted phospholipase A2 in the activation of human CD1-restricted T cells
PROJECT SUMMARY CD1 proteins are structurally related to MHC class I, but instead of peptides, they present lipid antigens to T cells. We and others have shown that CD1-restricted T cells recognizing self-lipids are abundant in the human T cell repertoire, yet it remains unclear how the activation of these T cells is regulated in vivo. Overt reactivity to self-lipids suggests that antigenic CD1-lipid complexes must be tightly regulated in order to prevent continuous T cell stimulation. Both fatty acids and lysophosphatidylcholine (LPC) have been identified as antigens for certain human CD1-restricted T cells. These lipids are released when the enzyme phospholipase A2 (PLA2) acts on membrane…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.