NIH R01 · 2024
The Role of the CES1 in the Pathogenesis of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by abnormally elevated pulmonary pressures and right heart failure resulting in high morbidity and mortality. The pathologic hallmark of PAH is progressive loss and obstructive remodeling of lung microvessels unresponsive to available therapies. Studies by our group and others have shown that pulmonary microvascular endothelial cells (PMVECs) derived from PAH patients are highly susceptible to apoptosis and have a lower capacity to form blood vessels (i.e., angiogenesis). Fatty acid oxidation (FAO) is an essential energy source for PMVECs that requires metabolic coupling of mitochondria and endoplasmic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.