NIH R01 · 2024
Discovery and validation of genetic variants affecting microglial activation in Alzheimer's disease
Project Summary/Abstract. While activated microglia have been observed in the vicinity of neuritic amyloid plaques in Alzheimer's disease (AD), there have been no large-scale assessments of microglial activation in aging and neurodegenerative disease. Our long-term goal is to understand the genetic underpinning of microglial responses—particularly the proportion of microglia in a morphologically-defined state of activation—that increase susceptibility to AD, so we can develop more targeted forms of immune-based therapies to prevent cognitive decline and progression to dementia. Our objective is to refine the genetic architecture of microglial activation to identify novel loci that influence…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.