NIH R01 · 2024
Identification of Genetic Variants that Influence Compulsive Alcohol Intake in Outbred Rats
Abstract Vulnerability to substance abuse and addiction has a heritable component. In particular, family and twin studies demonstrate that about 45-65% of the vulnerability to develop alcohol use disorder is determined by genetic factors. In the past decade, advances in genetics have provided critical clues in the search for the molecular basis of alcohol use and abuse. Human genome-wide association studies (GWAS) have expanded dramatically in size and sophistication, which has led to hundreds of loci being implicated in a range of alcohol- related traits. One major impediment to studies of alcohol use disorder is the complexity of the phenotype and the lack of control of environmental…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.