NIH R01 · 2024
Validation of imaging brain tumor metabolism using deuterated glucose
Aberrant metabolism is increasingly recognized as a hallmark of cancer. The Warburg effect is a well-known example of such abnormal cancer metabolism, which entails a shift away from oxidative to glycolytic glucose metabolism (despite the presence of oxygen) and usually also increased glucose uptake. The detection of this increased glucose uptake, via a radioactive analogue (2-18F-fluoro-2-deoxy-D-glucose, FDG) with positron emission tomography (PET), is often used for diagnosis, staging, and evaluating disease progression of tumors outside the brain. However, in patients with brain tumors FDG-PET is frequently inconclusive because the normal high glucose uptake in healthy brain is…
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