NIH R01 · 2025
Microglial lysosomes and selective neuronal vulnerability
Project Summary / Abstract The overall goal of this proposal is to reveal central regulators of microglial attributes that can impact synapses. Synaptic dysfunction is tightly linked to declining cognition and neuronal health during aging. A long- standing mystery in neuroscience is why some CNS neurons are more vulnerable to age-associated synapse loss and neurodegenerative disease. Microglia are well-positioned to influence synapses throughout the lifespan, being equipped to induce synapse formation, synapse elimination and alter synapse composition through multiple mechanisms. Moreover, synapse-relevant attributes of microglia change during aging, including their cell process motility,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.