Perkins Lab

Icahn School of Medicine at Mount Sinai

NEUROSCIENCES

New York · United States

NIH-funded
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NIH R01 · 2025

Spinal Sensory Ganglia and Gut Sensation

Project Summary The gut-brain axis, and in particular brain-stomach communication, are implicated in emotional and cognitive processing and often linked to many nervous system disorders, including psychosocial dysfunction, substance abuse, neurological diseases, and degeneration. While a large body of work exists on stomach-brain vagal pathways, much less is known about how the brain and the stomach may communicate through the spinal sensory pathways. This R01 application proposes to determine the anatomy, function, and circuitry targeted by gut-innervating spinal sensory ganglia. The proposed studies will test the overarching hypothesis that, similarly to musculoskeletal proprioception,…

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