NIH R01 · 2024
MIF Nuclease actions in Synuclein Dementias
Project Summary/Abstract: The pathologic accumulation of misfolded α-synuclein (α-syn) in neurons leads to neurodegeneration and cognitive dysfunction and dementia in a family of disorders designated α-synucleinopathies, which includes Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) dementia (PDD). DLB and PDD are clinically similar and share characteristic neuropathologic changes. Recent studies indicate that activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) contributes to the neurodegeneration induced by pathologic α-syn through the Parthanatos associated AIF (apoptosis-inducing factor) Nuclease (PAAN) also known as MIF, where PAAN/MIF is the executioner of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.