NIH R01 · 2025
Parthanatos, PAAN/MIF nuclease Activation in Ischemic Injury
Project Summary/Abstract: Stroke and other neurodegenerative disorders are a leading cause of death, disability, and loss of quality of life. The importance of glutamate neurotoxicity in cerebral ischemia and neurodegenerative diseases is well documented. Both in vitro and in vivo administration of glutamate and its analogs effectively kill neurons via excitotoxic mechanisms. Poly(ADP-ribose) polymerase-1 (PARP-1) is pivotal in glutamate neurotoxicity and cerebral infarction. Prior studies indicate that NO, or peroxynitrite plays a prominent role in glutamate excitotoxicity and cerebral infarction. Amongst other responses NO, or peroxynitrite, can activate PARP-1, which leads to cell death…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.