NIH R01 · 2024
Role of Tet enzymes in embryonic hematopoiesis
ABSTRACT The central objective of this proposal is to establish how Tet enzymes regulate the specification of blood cells from endothelial cells during embryonic hematopoiesis, and from pluripotent stem cells in vitro. During embryo- genesis, hematopoietic stem and progenitor cells (HSPCs) emerge from endothelial cells (ECs) in the arterial vasculature. A sub-population of ECs undergo an endothelial-to-hematopoietic transition (EHT) to specify hemogenic endothelial cells (HECs), which then give rise to HSPCs. This specification of ECs to HECs and to HSPCs is guided by timely expression of hematopoietic genes involving the Runx, Gata and Gfi1 family of transcription factors. While the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.