NIH R01 · 2024
PROJECT SUMMARY/ABSTRACT Cardiomyopathy patients are prone to ventricular arrhythmias (VA) and sudden death. Current therapies to prevent VA include radiofrequency ablation to destroy slowly conducting pathways of viable myocardium which support re-entry. Here we propose to test the reverse concept, namely that boosting local tissue viability in zones of slow conduction might eliminate slow conduction and suppress VA. We seek to do so by local injection, into mapped areas of slow conduction, of exosomes secreted by cardiosphere-derived cells (CDCs), a stromal/progenitor cell type from the human heart. Exosomes are extracellular vesicles laden with bioactive cargo. Those secreted by CDCs…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.