NIH R01 · 2024
Davoli/Mita Diversity Supplement
Summary of the funded parent grant Our cells are constantly exposed to (endogenous and exogenous) mutagens that cause DNA damage, which if left unrepaired, causes mutations. At the cellular level, the progressive accumulation of mutations in somatic tissues drives carcinogenesis and other diseases. Despite our large body of knowledge of DNA damage and repair in model organisms, we lack a deep understanding of this process in human tissues. What are the genetic causes of mutations in human tissues? How do different cell types control DNA damage and repair? Answering these questions is critical to understand how mutations lead to human diseases, such as carcinogenesis. Here we will use a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.