NIH R01 · 2024
Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia
PROJECT SUMMARY Dementia due to Alzheimer’s disease (AD) is a leading public health concern in the US with enormous care costs and no effective pharmacotherapy despite multiple clinical trials. Multiple studies have shown mild cognitive impairment (MCI) to be a precursor risk for AD and to be more amenable to intervention. While preclinical studies have shown that directly modulating activity in the prefrontal cortex (PFC) using non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS), can modulate cognitive function in healthy older adults, there is little evidence of reliable efficacy in MCI. We posit three reasons for this lack of efficacy. First, there…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.