NIH R01 · 2025
Predicting Relapse at the Time of Diagnosis in Acute Lymphoblastic Leukemia
PROJECT SUMMARY Relapse is the major cause of cancer related mortality in children with leukemia. Despite improvements in overall survival for children with B-cell progenitor acute lymphoblastic leukemia (ALL), for the 600 patients who will relapse each year, half will die of their disease. The high mortality of patients who relapse underscores the need for improved risk prediction and treatment strategies to prevent recurrent leukemia. Current approaches to relapse prediction are limited by insufficient accuracy, delayed prediction and the inability to make actionable treatment adjustments based on prediction information. To address these limitations, we applied a single-cell,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.