NIH R01 · 2024
Vibrio microcins. A hidden field of targeted anti-cholerae natural products.
Project Summary Cholera is a deadly diarrheal disease caused by the bacterial pathogen Vibrio cholerae. It remains poorly controlled in many parts of the world and outbreaks have been surging despite global efforts to reduce infection. New antibacterials for Gram-negative bacteria like V. cholerae are greatly needed but are also the most challenging to make because the outer membrane of these bacteria excludes nearly all molecules from entering the cell. An innovative strategy to overcome this permeability barrier is shown by the new clinical antibiotic cefiderocol, which binds outer membrane siderophore receptors and uses active transport systems to enter the periplasm. Unfortunately, few…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.