NIH R01 · 2024
Regulation of Endothelial Lipase and HDL Metabolism by ANGPTL3
PROJECT SUMMARY Despite currently available treatments, cardiovascular disease remains the leading cause of death in the United States. As dysregulated lipoprotein metabolism contribute to cardiovascular disease, there is a critical need to decipher the lipoprotein pathways, including those regulated by ANGPTL proteins, that drive cardiovascular pathologies. The long-term goal of the proposed research is to understand how ANGPTL proteins regulate lipid homeostasis and how these proteins become dysregulated in disease. One ANGPTL protein, the hepatokine ANGPTL3, inhibits both endothelial lipase (EL) and lipoprotein lipase, and thus regulates both plasma cholesterol and triglycerides. The…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.