NIH R01 · 2025
PROJECT SUMMARY Progressive loss of kidney function in chronic kidney disease (CKD) is associated with adverse clinical outcomes including inflammation, anemia, and bone and mineral disorders that contribute to cardiovascular events and increased mortality. Limited knowledge of molecular mechanisms that contribute to CKD progression impedes development of desperately needed therapeutics aimed at reducing morbidity and mortality in patients with CKD. Expression of hepatocyte nuclear factor 4 alpha (Hnf4α) is dramatically reduced in bone and kidney from patients and animals with CKD, but the role of HNF4α in CKD progression and CKD-associated outcomes is unknown. In preliminary data for this…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.