David Lab

Duke University

GENETICS

Durham · United States

NIH-funded
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NIH R01 · 2025

Dietary plant diversity and the human gut microbiome

ABSTRACT: Food shapes gut microbial communities and their impact on human health. Thus, rationally designed diets based on gut microbial ecology could provide a cost-effective intervention that significantly improves public health. Still, there are hundreds of edible food species and thousands of unique gut bacterial taxa. Do basic dietary rules govern microbial systems of this complexity? One intriguing observation has been that the diversity of ingested plant species is linked to gut microbiome structure. However, it remains unknown if and how relationships between dietary diversity and the gut microbiome generalize across diverse human populations. Moreover, we do not know how diets…

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