NIH R01 · 2024
L-Arg availability affects the physiological state of porphyromonas gingivalis.
Project Summary/Abstract Many chronic inflammatory diseases, including periodontal infections, are biofilm-based pathologies mediated by indigenous microbiota persisting within complex host-associated microbial communities. Determining the environmental cues that direct the physiological state (commensal versus pathogenic state) of oral anaerobes, is fundamental to development of therapeutic strategies for periodontal diseases. Recent studies indicate that the pathogenic potential of the anaerobic bacterium Porphyromonas gingivalis is not solely dependent on its ability to colonize and proliferate within the subgingival biofilm; its physiological state and its associations within the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.