NIH R01 · 2024
Functional impact, mechanistic role, and targetability of ROS1 aberrations in cancer
PROJECT SUMMARY Chromosomal rearrangements of the proto-oncogene ROS1 produce constitutively active ROS1 kinase-fusion proteins that are established as druggable pathogenic drivers in human cancer. Currently, this is the only validated mechanism of aberrant ROS1 activation in oncogenesis. ROS1 is targetable with multiple tyrosine kinase inhibitors (TKI), and significant tumor regression is observed in ROS1-fusion positive patients who are treated with targeted TKI. Cancer genome sequencing studies reveal numerous ROS1 somatic mutations but their impact on catalytic function has not been tested, prompting new questions about ROS1-driven cancer pathogenesis. Further, the mechanistic role of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.