NIH R01 · 2024
Neurobehavioral phenotyping of AD model mice using Motion Sequencing
Abstract Alzheimer's disease (AD) is caused by progressive changes in neural circuits that culminate in memory loss, confusion, difficulty completing tasks, withdrawal, mood changes and ultimately death. Alterations in body movement — such as slowed gait, and difficulty in avoiding obstacles — have been associated with AD, are predictive of AD, and often appear in the pre-clinical stage, before cognitive changes are apparent. These observations raise important questions about how AD targets the cognitive and motor systems that support movement and/or action selection; addressing these questions in turn requires a clear view of how AD pathophysiology influences behavior both early and late…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.