NIH R01 · 2025
Mechanistic basis of exercise responses in liver disease
Sarcopenia, or loss of skeletal muscle mass, with impaired contractile function that causes physical frailty and decreased exercise capacity are frequent in cirrhosis and contribute to adverse clinical outcomes. Exercise training improves some measures of muscle mass and exercise capacity but the mechanistic basis of these responses in cirrhosis is not known. In healthy subjects, endurance exercise (EE) improves maximum oxygen consumption (VO2max) while resistance exercise (RE) increases muscle mass and strength. In patients with cirrhosis, an increase in muscle mass improves survival. In contrast, higher VO2max is associated with better survival but whether an increase in VO2max translates…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.